Assay Detail
Functional
CHEMBL4371122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OK-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor (CHEMBL1793) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.19 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439458 | — | — | 1 | 8.36 |
| CHEMBL424859 | — | — | 1 | 8.26 |
| CHEMBL276472 | — | — | 1 | 8.10 |
| CHEMBL428635 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439458 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL424859 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL276472 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL428635 | — | EC50 | = | 9.1 | nM | 8.04 |