Assay Detail
Binding
CHEMBL4371137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human type 2 5alpha reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.99 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 9.74 |
| CHEMBL4569322 | — | — | 1 | 8.74 |
| CHEMBL4540042 | — | — | 1 | 8.48 |
| CHEMBL1200969 | DUTASTERIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4569322 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4540042 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1200969 | DUTASTERIDE | IC50 | < | 0.1 | nM | - |