Assay Detail
Binding
CHEMBL4371211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.17 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297299 | KX2-361 | 1.0 | 1 | 4.17 |
| CHEMBL571546 | TIRBANIBULIN | 4.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297299 | KX2-361 | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL571546 | TIRBANIBULIN | IC50 | = | 67000.0 | nM | 4.17 |