Assay Detail
Binding
CHEMBL4371598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.00 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563342 | — | — | 1 | 7.80 |
| CHEMBL260549 | — | — | 1 | 7.60 |
| CHEMBL551790 | — | — | 1 | 7.40 |
| CHEMBL492677 | — | — | 1 | 7.20 |
| CHEMBL2047474 | — | — | 1 | 6.00 |
| CHEMBL1688969 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563342 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL260549 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL551790 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL492677 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL2047474 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1688969 | — | EC50 | = | 1000.0 | nM | 6.00 |