Assay Detail
Binding
CHEMBL4371644
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Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as increase in ERK1/2 phosphorylation after 5 mins by alphascreen assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.09 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464176 | — | — | 1 | 9.80 |
| CHEMBL119709 | IB-MECA | — | 1 | 9.60 |
| CHEMBL2064653 | — | — | 1 | 9.30 |
| CHEMBL2064657 | — | — | 1 | 8.10 |
| CHEMBL2064660 | — | — | 1 | 7.60 |
| CHEMBL2064661 | — | — | 1 | 6.20 |
| CHEMBL2064634 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464176 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL119709 | IB-MECA | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL2064653 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL2064657 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL2064660 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2064661 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL2064634 | — | EC50 | = | 1000.0 | nM | 6.00 |