Assay Detail
Binding
CHEMBL4371649
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Agonist activity at adenosine A3 receptor (unknown origin) expressed in serum starved CHO cells assessed as increase in cell survival after 24 hrs by propidium iodide staining-based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.11 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464176 | — | — | 1 | 10.20 |
| CHEMBL2064653 | — | — | 1 | 9.70 |
| CHEMBL2064660 | — | — | 1 | 9.60 |
| CHEMBL2064657 | — | — | 1 | 9.50 |
| CHEMBL119709 | IB-MECA | — | 1 | 9.20 |
| CHEMBL2064661 | — | — | 1 | 7.90 |
| CHEMBL2064634 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464176 | — | EC50 | = | 0.0631 | nM | 10.20 |
| CHEMBL2064653 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL2064660 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL2064657 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL119709 | IB-MECA | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL2064661 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL2064634 | — | EC50 | = | 19.95 | nM | 7.70 |