Assay Detail
Binding
CHEMBL4371655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Rluc8 fused human GLP1 receptor expressed in HEK293 cells assessed co-expressing GFP-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment after 20 to 40 mins by BRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.00 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410972 | — | — | 1 | 8.10 |
| CHEMBL4533613 | — | — | 1 | 8.00 |
| CHEMBL4445245 | — | — | 1 | 8.00 |
| CHEMBL4471698 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410972 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4533613 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4445245 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4471698 | — | EC50 | = | 12.59 | nM | 7.90 |