Assay Detail
Functional
CHEMBL4371709
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Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTS assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471209 | — | — | 1 | 8.70 |
| CHEMBL4469081 | — | — | 1 | 8.52 |
| CHEMBL4434719 | — | — | 1 | 8.52 |
| CHEMBL4541096 | — | — | 1 | 8.30 |
| CHEMBL4580102 | — | — | 1 | 8.30 |
| CHEMBL4434736 | — | — | 1 | 8.30 |
| CHEMBL4546156 | — | — | 1 | 8.00 |
| CHEMBL4448256 | — | — | 1 | 7.89 |
| CHEMBL2103884 | OPROZOMIB | 2.0 | 1 | 7.72 |
| CHEMBL4559176 | — | — | 1 | 7.70 |
| CHEMBL4465844 | — | — | 1 | 7.50 |
| CHEMBL4453760 | — | — | 1 | 7.26 |
| CHEMBL4472844 | — | — | 1 | 7.14 |
| CHEMBL4585963 | — | — | 1 | 7.13 |
| CHEMBL4536411 | — | — | 1 | 7.09 |
| CHEMBL4536022 | — | — | 1 | 6.92 |
| CHEMBL4536377 | — | — | 1 | 6.89 |
| CHEMBL4466983 | — | — | 1 | 6.46 |
| CHEMBL4440926 | — | — | 1 | - |
| CHEMBL4565982 | — | — | 1 | - |
| CHEMBL4449200 | — | — | 1 | - |
| CHEMBL4560321 | — | — | 1 | - |
| CHEMBL4592762 | — | — | 1 | - |
| CHEMBL4458777 | — | — | 1 | - |
| CHEMBL4591075 | — | — | 1 | - |
| CHEMBL4444275 | — | — | 1 | - |
| CHEMBL4530484 | — | — | 1 | - |
| CHEMBL4464002 | — | — | 1 | - |
| CHEMBL4449881 | — | — | 1 | - |
| CHEMBL4447069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471209 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4469081 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4434719 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4541096 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4580102 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4434736 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4546156 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4448256 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2103884 | OPROZOMIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4559176 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4465844 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4453760 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4472844 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4585963 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4536411 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4536022 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4536377 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4466983 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4440926 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4565982 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4449200 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4560321 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4592762 | — | IC50 | - | — | - | |
| CHEMBL4458777 | — | IC50 | - | — | - | |
| CHEMBL4591075 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4444275 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4530484 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4464002 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4449881 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4447069 | — | IC50 | - | — | - | |
| CHEMBL4461405 | — | IC50 | - | — | - |