Assay Detail
Functional
CHEMBL4371841
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Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.37 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509175 | RORIDIN E | — | 1 | 10.30 |
| CHEMBL4525219 | — | — | 1 | 8.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL4540831 | — | — | 1 | 7.10 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.68 |
| CHEMBL4524286 | — | — | 1 | 5.47 |
| CHEMBL4549565 | — | — | 1 | - |
| CHEMBL4583127 | — | — | 1 | - |
| CHEMBL4516810 | — | — | 1 | - |
| CHEMBL4465445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509175 | RORIDIN E | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4525219 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4540831 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4524286 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4549565 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4583127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4516810 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4465445 | — | IC50 | > | 10000.0 | nM | - |