Assay Detail
Functional
CHEMBL4371906
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Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected in type A-positive human erythrocytes after 72 hrs by SYBR green 1 dye-based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.09 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.59 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 8.08 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.01 |
| CHEMBL4464814 | — | — | 1 | 7.07 |
| CHEMBL1170653 | — | — | 1 | 6.59 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.85 |
| CHEMBL23236 | BETULIN | — | 1 | 5.41 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4464814 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1170653 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL269277 | BETULINIC ACID | EC50 | = | 1419.0 | nM | 5.85 |
| CHEMBL23236 | BETULIN | EC50 | = | 3938.0 | nM | 5.41 |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - |