Assay Detail
Binding
CHEMBL4372114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of histone activated chicken PDE6 using [3H]cGMP as substrate measured after 10 mins by scintillation counting method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N<sup>2</sup>,N<sup>4</sup>-diaminoquinazoline based inhibitors of phosphodiesterase type 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.33 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.89 |
| CHEMBL4529354 | — | — | 1 | 6.72 |
| CHEMBL4445920 | — | — | 1 | 6.48 |
| CHEMBL4570769 | — | — | 1 | 6.44 |
| CHEMBL4453311 | — | — | 1 | 6.35 |
| CHEMBL4534674 | — | — | 1 | 6.21 |
| CHEMBL597248 | — | — | 1 | 6.05 |
| CHEMBL4565213 | — | — | 1 | 4.47 |
| CHEMBL4540726 | — | — | 1 | - |
| CHEMBL4450878 | — | — | 1 | - |
| CHEMBL4469064 | — | — | 1 | - |
| CHEMBL4558761 | — | — | 1 | - |
| CHEMBL4526365 | — | — | 1 | - |
| CHEMBL4452377 | — | — | 1 | - |
| CHEMBL4525521 | — | — | 1 | - |
| CHEMBL4567109 | — | — | 1 | - |
| CHEMBL4544782 | — | — | 1 | - |
| CHEMBL4460740 | — | — | 1 | - |
| CHEMBL4434898 | — | — | 1 | - |
| CHEMBL4552918 | — | — | 1 | - |
| CHEMBL4516390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4529354 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4445920 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL4570769 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4453311 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4534674 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL597248 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4565213 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL4540726 | — | IC50 | - | — | - | |
| CHEMBL4450878 | — | IC50 | - | — | - | |
| CHEMBL4469064 | — | IC50 | - | — | - | |
| CHEMBL4558761 | — | IC50 | - | — | - | |
| CHEMBL4526365 | — | IC50 | - | — | - | |
| CHEMBL4452377 | — | IC50 | - | — | - | |
| CHEMBL4525521 | — | IC50 | - | — | - | |
| CHEMBL4567109 | — | IC50 | - | — | - | |
| CHEMBL4544782 | — | IC50 | - | — | - | |
| CHEMBL4460740 | — | IC50 | - | — | - | |
| CHEMBL4434898 | — | IC50 | - | — | - | |
| CHEMBL4552918 | — | IC50 | - | — | - | |
| CHEMBL4516390 | — | IC50 | - | — | - |