Assay Detail
ADMET
CHEMBL4372116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N<sup>2</sup>,N<sup>4</sup>-diaminoquinazoline based inhibitors of phosphodiesterase type 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.85 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445920 | — | — | 1 | 4.95 |
| CHEMBL4534674 | — | — | 1 | 4.94 |
| CHEMBL4453311 | — | — | 1 | 4.92 |
| CHEMBL597248 | — | — | 1 | 4.91 |
| CHEMBL4570769 | — | — | 1 | 4.82 |
| CHEMBL4529354 | — | — | 1 | 4.57 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445920 | — | IC50 | = | 11150.0 | nM | 4.95 |
| CHEMBL4534674 | — | IC50 | = | 11370.0 | nM | 4.94 |
| CHEMBL4453311 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL597248 | — | IC50 | = | 12290.0 | nM | 4.91 |
| CHEMBL4570769 | — | IC50 | = | 15040.0 | nM | 4.82 |
| CHEMBL4529354 | — | IC50 | = | 26920.0 | nM | 4.57 |
| CHEMBL192 | SILDENAFIL | IC50 | - | — | - |