Assay Detail
Functional
CHEMBL4372118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in Wistar rat endothelium intact pulmonary artery rings assessed as inhibition of phenylephrine-induced contraction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N<sup>2</sup>,N<sup>4</sup>-diaminoquinazoline based inhibitors of phosphodiesterase type 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.09 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.85 |
| CHEMBL4445920 | — | — | 1 | 5.79 |
| CHEMBL4570769 | — | — | 1 | 5.64 |
| CHEMBL4529354 | — | — | 1 | - |
| CHEMBL4534674 | — | — | 1 | - |
| CHEMBL4453311 | — | — | 1 | - |
| CHEMBL597248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4445920 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4570769 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4529354 | — | EC50 | - | — | - | |
| CHEMBL4534674 | — | EC50 | - | — | - | |
| CHEMBL4453311 | — | EC50 | - | — | - | |
| CHEMBL597248 | — | EC50 | - | — | - |