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Assay Detail

CHEMBL4372128

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Functional
Antiviral activity against Poliovirus Sabin 3 infected in human HeLa cells assessed as reduction in virus-induced cytopathic effect after 72 hrs by crystal violet staining-based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Poliovirus 3
Confidence 1 — Organism
Curated By Autocuration

Target

Poliovirus 3 (CHEMBL613557)
Type ORGANISM
Organism Poliovirus 3

Publication

In Vitro Antiviral Activity of New Oxazoline Derivatives as Potent Poliovirus Inhibitors.
Madia VN, Messore A, Pescatori L, Saccoliti F, Tudino V, De Leo A, Scipione L, Fiore L, Rhoden E, Manetti F, Oberste MS, Di Santo R, Costi R.
J Med Chem (2019) 62 : 798 -810
PubMed 30512950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.52 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298019 PIRODAVIR 2.0 1 8.10
CHEMBL1235858 1 7.70
CHEMBL4542831 1 7.28
CHEMBL141157 IMOCITRELVIR 2.0 1 6.86
CHEMBL4521854 1 6.66
CHEMBL4440889 1 6.48
CHEMBL166427 1 6.43
CHEMBL4530638 1 6.28
CHEMBL4445068 1 5.88
CHEMBL4441207 1 5.04
CHEMBL4475409 1 5.04
CHEMBL4525235 1 -
CHEMBL4514035 1 -
CHEMBL4458154 1 -
CHEMBL4588998 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298019 PIRODAVIR EC50 = 8.0 nM 8.10
CHEMBL1235858 EC50 = 20.0 nM 7.70
CHEMBL4542831 EC50 = 53.0 nM 7.28
CHEMBL141157 IMOCITRELVIR EC50 = 137.0 nM 6.86
CHEMBL4521854 EC50 = 218.0 nM 6.66
CHEMBL4440889 EC50 = 330.0 nM 6.48
CHEMBL166427 EC50 = 367.0 nM 6.43
CHEMBL4530638 EC50 = 530.0 nM 6.28
CHEMBL4445068 EC50 = 1323.0 nM 5.88
CHEMBL4441207 EC50 = 9160.0 nM 5.04
CHEMBL4475409 EC50 = 9070.0 nM 5.04
CHEMBL4525235 EC50 > 10000.0 nM -
CHEMBL4514035 EC50 > 10000.0 nM -
CHEMBL4458154 EC50 > 10000.0 nM -
CHEMBL4588998 EC50 > 10000.0 nM -