Assay Detail
Binding
CHEMBL4372232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MT1-MMP catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 min by fluorometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.72 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617407 | — | — | 1 | 8.41 |
| CHEMBL4584813 | — | — | 1 | 8.15 |
| CHEMBL4518217 | — | — | 1 | 7.85 |
| CHEMBL267178 | — | — | 1 | 7.64 |
| CHEMBL1090647 | — | — | 1 | 7.47 |
| CHEMBL4466038 | — | — | 1 | 7.39 |
| CHEMBL4442617 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617407 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4584813 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4518217 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL267178 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1090647 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4466038 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4442617 | — | IC50 | = | 80.0 | nM | 7.10 |