Assay Detail
Binding
CHEMBL4372810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 recruitment after overnight incubation by BrightGlo reagent based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.60 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069231 | — | — | 1 | 8.42 |
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 8.29 |
| CHEMBL4582146 | — | — | 1 | 8.10 |
| CHEMBL4467644 | — | — | 1 | 7.92 |
| CHEMBL4462000 | — | — | 1 | 7.77 |
| CHEMBL4561040 | — | — | 1 | 7.48 |
| CHEMBL4483681 | — | — | 1 | 7.38 |
| CHEMBL4463652 | — | — | 1 | 7.37 |
| CHEMBL4555496 | — | — | 1 | 6.64 |
| CHEMBL4438714 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069231 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL445332 | SALVINORIN A | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4582146 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4467644 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4462000 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4561040 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4483681 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4463652 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4555496 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4438714 | — | EC50 | = | 247.0 | nM | 6.61 |