Assay Detail
Binding
CHEMBL4372844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Selectivity ratio of Ki for displacement of [3H]DOI from recombinant human 5HT2A receptor expressed in HEK293T cell membranes to Ki for displacement of [3H]DOI from recombinant human 5HT2C receptor expressed in HEK293T cell membranes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 receptors; 5-HT2a & 5-HT2c (CHEMBL2096662) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT2C receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.12 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360328 | LORCASERIN | 4.0 | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360328 | LORCASERIN | Ki | = | 7.5 | nM | 8.12 |