Assay Detail
Binding
CHEMBL4373005
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Inhibition of human ERG
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.49 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457529 | — | — | 1 | 8.96 |
| CHEMBL4466764 | — | — | 1 | 8.85 |
| CHEMBL4528544 | — | — | 1 | 8.77 |
| CHEMBL4540910 | — | — | 1 | 8.52 |
| CHEMBL4470576 | — | — | 1 | 8.52 |
| CHEMBL4445116 | — | — | 1 | 8.52 |
| CHEMBL4541837 | — | — | 1 | 8.40 |
| CHEMBL4518492 | — | — | 2 | 8.30 |
| CHEMBL4457389 | — | — | 1 | 8.30 |
| CHEMBL4583118 | — | — | 2 | 8.22 |
| CHEMBL4563802 | — | — | 1 | - |
| CHEMBL4446498 | — | — | 1 | - |
| CHEMBL4533366 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457529 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4466764 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4528544 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4540910 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4470576 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4445116 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4541837 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4518492 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4457389 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4583118 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4518492 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4563802 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL4446498 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL4533366 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL4583118 | — | IC50 | > | 20.0 | nM | - |