Assay Detail
Functional
CHEMBL4373129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-sensitive final late stage of Plasmodium falciparum NF54-Mal8p1.16-GFP-Luc gametocytes after 24 hrs by BacTiter-Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.97 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571751 | — | — | 1 | 6.68 |
| CHEMBL4468890 | — | — | 1 | 6.57 |
| CHEMBL4459380 | — | — | 1 | 6.43 |
| CHEMBL4549480 | — | — | 1 | 6.22 |
| CHEMBL4577940 | — | — | 1 | 6.16 |
| CHEMBL4464908 | — | — | 1 | 6.13 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.05 |
| CHEMBL4457843 | — | — | 1 | 5.78 |
| CHEMBL4466654 | — | — | 1 | 5.70 |
| CHEMBL4443956 | — | — | 1 | 5.61 |
| CHEMBL4576616 | — | — | 1 | 5.48 |
| CHEMBL367149 | DOCONEXENT | 3.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571751 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4468890 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4459380 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4549480 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4577940 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4464908 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4457843 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4466654 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4443956 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4576616 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL367149 | DOCONEXENT | IC50 | = | 14000.0 | nM | 4.85 |