Assay Detail
ADMET
CHEMBL4373209
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Cytotoxicity against human A549 cells after 48 hrs by CellTiter-Glo assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 4.80 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444802 | — | — | 1 | 6.40 |
| CHEMBL4549411 | — | — | 1 | 5.23 |
| CHEMBL4476496 | — | — | 1 | 4.59 |
| CHEMBL4551942 | — | — | 1 | 4.56 |
| CHEMBL4575669 | — | — | 1 | 4.38 |
| CHEMBL3770879 | — | — | 1 | 4.24 |
| CHEMBL4483092 | — | — | 1 | 4.18 |
| CHEMBL4446383 | — | — | 1 | - |
| CHEMBL4469279 | — | — | 1 | - |
| CHEMBL4472140 | — | — | 1 | - |
| CHEMBL4585066 | — | — | 1 | - |
| CHEMBL4561263 | — | — | 1 | - |
| CHEMBL4448860 | — | — | 1 | - |
| CHEMBL4442349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444802 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4549411 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4476496 | — | EC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL4551942 | — | EC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL4575669 | — | EC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL3770879 | — | EC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL4483092 | — | EC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL4446383 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4469279 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4472140 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4585066 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4561263 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4448860 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL4442349 | — | EC50 | >= | 100000.0 | nM | - |