Assay Detail
ADMET
CHEMBL4373233
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Inhibition of CYP2C8 in human liver microsomes
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 13 | - | - |
| IC50 | 2 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279180 | — | — | 1 | 6.00 |
| CHEMBL4550045 | — | — | 1 | 6.00 |
| CHEMBL4570932 | — | — | 1 | - |
| CHEMBL4466131 | — | — | 1 | - |
| CHEMBL4527346 | — | — | 1 | - |
| CHEMBL4292013 | — | — | 1 | - |
| CHEMBL4290933 | — | — | 1 | - |
| CHEMBL4276864 | — | — | 1 | - |
| CHEMBL4283748 | — | — | 1 | - |
| CHEMBL4475017 | — | — | 1 | - |
| CHEMBL4447807 | — | — | 1 | - |
| CHEMBL4287506 | — | — | 1 | - |
| CHEMBL4524193 | — | — | 1 | - |
| CHEMBL4280298 | — | — | 1 | - |
| CHEMBL4460464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279180 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4550045 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4570932 | — | Inhibition | - | % | - | |
| CHEMBL4466131 | — | Inhibition | - | % | - | |
| CHEMBL4527346 | — | Inhibition | - | % | - | |
| CHEMBL4292013 | — | Inhibition | - | % | - | |
| CHEMBL4290933 | — | Inhibition | - | % | - | |
| CHEMBL4276864 | — | Inhibition | - | % | - | |
| CHEMBL4283748 | — | Inhibition | - | % | - | |
| CHEMBL4475017 | — | Inhibition | - | % | - | |
| CHEMBL4447807 | — | Inhibition | - | % | - | |
| CHEMBL4287506 | — | Inhibition | - | % | - | |
| CHEMBL4524193 | — | Inhibition | - | % | - | |
| CHEMBL4280298 | — | Inhibition | - | % | - | |
| CHEMBL4460464 | — | Inhibition | - | % | - |