Assay Detail
Binding
CHEMBL4373256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL3414411) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.04 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061793 | — | — | 1 | 8.74 |
| CHEMBL4290933 | — | — | 1 | 8.30 |
| CHEMBL4279180 | — | — | 1 | 7.96 |
| CHEMBL4276864 | — | — | 1 | 7.92 |
| CHEMBL4280298 | — | — | 1 | 7.92 |
| CHEMBL4550045 | — | — | 1 | 7.85 |
| CHEMBL4287506 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061793 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4290933 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4279180 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4276864 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4280298 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4550045 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4287506 | — | IC50 | = | 24.0 | nM | 7.62 |