Assay Detail
Functional
CHEMBL4373335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protection against copy of c-myc-tagged human bax gene induced toxicity in yeast BC300 assessed as restoration of cell growth in SG liquid medium measured after 72 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Saccharomyces cerevisiae |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.07 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909875 | AEGELINE | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909875 | AEGELINE | EC50 | = | 850.0 | nM | 6.07 |