Assay Detail
Binding
CHEMBL4373370
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Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.54 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573271 | — | — | 1 | 4.62 |
| CHEMBL39878 | — | — | 1 | 4.55 |
| CHEMBL4561568 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573271 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL39878 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4561568 | — | EC50 | = | 35000.0 | nM | 4.46 |