Assay Detail
Binding
CHEMBL4373434
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Inhibition of Wnt3a activated Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase preincubated with cells followed by Wnt3a addition and measured after 24 hrs by luciferase reporter gene assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.76 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588097 | — | — | 1 | 8.92 |
| CHEMBL4454905 | — | — | 1 | 8.39 |
| CHEMBL4443889 | — | — | 1 | 8.33 |
| CHEMBL4518078 | — | — | 1 | 8.12 |
| CHEMBL4483450 | — | — | 1 | 7.75 |
| CHEMBL4587547 | — | — | 1 | 7.60 |
| CHEMBL4466405 | — | — | 1 | 7.47 |
| CHEMBL4483069 | — | — | 1 | 6.85 |
| CHEMBL4457105 | — | — | 1 | 6.64 |
| CHEMBL4534612 | — | — | 1 | 6.57 |
| CHEMBL4446719 | — | — | 1 | 6.41 |
| CHEMBL1201303 | PYRVINIUM | 4.0 | 1 | 6.12 |
| CHEMBL4439672 | — | — | 1 | 6.08 |
| CHEMBL4524301 | — | — | 1 | 5.92 |
| CHEMBL4458449 | — | — | 1 | 5.89 |
| CHEMBL4462558 | — | — | 1 | 5.72 |
| CHEMBL4472031 | — | — | 1 | 5.31 |
| CHEMBL4584567 | — | — | 1 | 5.26 |
| CHEMBL4566481 | — | — | 1 | 5.06 |
| CHEMBL4439010 | — | — | 1 | - |
| CHEMBL4465410 | — | — | 1 | - |
| CHEMBL4438746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588097 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4454905 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4443889 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4518078 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4483450 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4587547 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4466405 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4483069 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4457105 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4534612 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4446719 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1201303 | PYRVINIUM | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4439672 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4524301 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4458449 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4462558 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4472031 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4584567 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4566481 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4439010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4465410 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438746 | — | IC50 | > | 10000.0 | nM | - |