Assay Detail
Binding
CHEMBL4373757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human STING expressed in Escherichia coli by isothermal titration calorimetric method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.77 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465054 | — | — | 1 | 8.42 |
| CHEMBL4449584 | — | — | 1 | 5.98 |
| CHEMBL1231573 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465054 | — | Kd | = | 3.79 | nM | 8.42 |
| CHEMBL4449584 | — | Kd | = | 1040.0 | nM | 5.98 |
| CHEMBL1231573 | — | Kd | = | 1210.0 | nM | 5.92 |