Assay Detail
Functional
CHEMBL4373850
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Antiproliferative activity against human U937 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer <i>via</i> small molecule potentiators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.18 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537024 | — | — | 1 | 5.23 |
| CHEMBL4569822 | — | — | 1 | 5.13 |
| CHEMBL1734430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537024 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4569822 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1734430 | — | IC50 | > | 20000.0 | nM | - |