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Assay Detail

CHEMBL4374193

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO-K1
Confidence 1 — Organism
Curated By Autocuration

Target

CHO-K1 (CHEMBL614031)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin.
Dziwornu GA, Kamunya S, Ntsabo T, Chibale K.
Medchemcomm (2019) 10 : 961 -969
PubMed 31303994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 4.59 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50588 EMETINE 4.0 1 7.70
CHEMBL4450530 1 5.08
CHEMBL4447244 1 4.74
CHEMBL4471758 1 4.52
CHEMBL4539810 1 4.43
CHEMBL4568437 1 4.40
CHEMBL4446171 1 4.40
CHEMBL4474329 1 4.37
CHEMBL4584850 1 4.37
CHEMBL4587993 1 4.36
CHEMBL4528791 1 4.35
CHEMBL4521190 1 4.34
CHEMBL4456681 1 4.34
CHEMBL4524563 1 4.34
CHEMBL4475264 1 4.34
CHEMBL4441894 1 4.34
CHEMBL4524432 1 4.33
CHEMBL4464164 1 4.32
CHEMBL4473784 1 4.32
CHEMBL4539181 1 4.32
CHEMBL4513661 1 -
CHEMBL4592422 1 -
CHEMBL4457631 1 -
CHEMBL4513781 1 -
CHEMBL4543544 1 -
CHEMBL4587841 1 -
CHEMBL4578741 1 -
CHEMBL4532071 1 -
CHEMBL4593107 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50588 EMETINE IC50 = 20.0 nM 7.70
CHEMBL4450530 IC50 = 8240.0 nM 5.08
CHEMBL4447244 IC50 = 18160.0 nM 4.74
CHEMBL4471758 IC50 = 30200.0 nM 4.52
CHEMBL4539810 IC50 = 36840.0 nM 4.43
CHEMBL4568437 IC50 = 40200.0 nM 4.40
CHEMBL4446171 IC50 = 39900.0 nM 4.40
CHEMBL4474329 IC50 = 42880.0 nM 4.37
CHEMBL4584850 IC50 = 42680.0 nM 4.37
CHEMBL4587993 IC50 = 44100.0 nM 4.36
CHEMBL4528791 IC50 = 44690.0 nM 4.35
CHEMBL4521190 IC50 = 45950.0 nM 4.34
CHEMBL4456681 IC50 = 45300.0 nM 4.34
CHEMBL4524563 IC50 = 45150.0 nM 4.34
CHEMBL4475264 IC50 = 45390.0 nM 4.34
CHEMBL4441894 IC50 = 46130.0 nM 4.34
CHEMBL4524432 IC50 = 47120.0 nM 4.33
CHEMBL4464164 IC50 = 47900.0 nM 4.32
CHEMBL4473784 IC50 = 47400.0 nM 4.32
CHEMBL4539181 IC50 = 47610.0 nM 4.32
CHEMBL4513661 IC50 > 50000.0 nM -
CHEMBL4592422 IC50 > 50000.0 nM -
CHEMBL4457631 IC50 > 50000.0 nM -
CHEMBL4513781 IC50 > 50000.0 nM -
CHEMBL4543544 IC50 > 50000.0 nM -
CHEMBL4587841 IC50 > 50000.0 nM -
CHEMBL4578741 IC50 > 50000.0 nM -
CHEMBL4532071 IC50 > 50000.0 nM -
CHEMBL4593107 IC50 > 50000.0 nM -