Assay Detail
Binding
CHEMBL4374339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of <i>Flaviviridae</i> viruses and <i>Trypanosoma</i> species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.87 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137312 | DASABUVIR | 4.0 | 1 | 8.74 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137312 | DASABUVIR | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 102.0 | nM | 6.99 |