Assay Detail
Functional
CHEMBL4374583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DNA alkylating activity in human A549 cells exhibiting increased cathepsin B activity and overexpressing GCPII assessed as reduction in cell viability incubated for 72 hrs by MTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.98 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443767 | — | — | 1 | 7.44 |
| CHEMBL4452530 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443767 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL4452530 | — | IC50 | = | 309.0 | nM | 6.51 |