Assay Detail
Functional
CHEMBL4374589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DNA alkylating activity in GCPII negative human PC3 cells exhibiting increased cathepsin B activity assessed as reduction in cell viability incubated with GCPII binder 2-PMPA for 1 hr followed by incubation with compound for 48 hrs by MTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.21 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443767 | — | — | 1 | 8.21 |
| CHEMBL4452530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443767 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4452530 | — | IC50 | > | 100000.0 | nM | - |