Assay Detail
Binding
CHEMBL4374980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus ATCC 29213 DNA gyrase A assessed as reduction in enzyme-mediated supercoiling of relaxed pBR322 DNA by ethidium bromide staining based gel electrophoresis method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583368 | — | — | 1 | 7.70 |
| CHEMBL4541988 | — | — | 1 | 7.70 |
| CHEMBL4530328 | — | — | 1 | 6.22 |
| CHEMBL4438807 | — | — | 1 | 6.10 |
| CHEMBL4569403 | — | — | 1 | 5.96 |
| CHEMBL4533152 | — | — | 1 | 5.96 |
| CHEMBL4441397 | — | — | 1 | 5.92 |
| CHEMBL4575351 | — | — | 1 | 5.89 |
| CHEMBL4536608 | — | — | 1 | 5.82 |
| CHEMBL4465361 | — | — | 1 | 5.80 |
| CHEMBL4465692 | — | — | 1 | 5.68 |
| CHEMBL4537564 | — | — | 1 | 5.58 |
| CHEMBL4445613 | — | — | 1 | 5.55 |
| CHEMBL4591085 | — | — | 1 | 5.44 |
| CHEMBL4548671 | — | — | 1 | 5.43 |
| CHEMBL4467826 | — | — | 1 | 5.41 |
| CHEMBL4570423 | — | — | 1 | 5.35 |
| CHEMBL4583024 | — | — | 1 | 5.34 |
| CHEMBL4567626 | — | — | 1 | 5.28 |
| CHEMBL4549719 | — | — | 1 | 5.25 |
| CHEMBL4554663 | — | — | 1 | 5.17 |
| CHEMBL4538641 | — | — | 1 | 5.16 |
| CHEMBL4476525 | — | — | 1 | 5.11 |
| CHEMBL4527338 | — | — | 1 | 5.02 |
| CHEMBL4544202 | — | — | 1 | 4.98 |
| CHEMBL4538428 | — | — | 1 | 4.92 |
| CHEMBL4585210 | — | — | 1 | 4.92 |
| CHEMBL4531900 | — | — | 1 | 4.85 |
| CHEMBL4453182 | — | — | 1 | 4.77 |
| CHEMBL4453061 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583368 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4541988 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4530328 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4438807 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4569403 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4533152 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4441397 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4575351 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4536608 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4465361 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4465692 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4537564 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4445613 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4591085 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4548671 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4467826 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4570423 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4583024 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4567626 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4549719 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4554663 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4538641 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4476525 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4527338 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4544202 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4538428 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4585210 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4531900 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4453182 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4453061 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4544573 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4451890 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL579300 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4515683 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL4530941 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL4435611 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL4574863 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4557243 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 187000.0 | nM | - |
| CHEMBL4559061 | — | IC50 | > | 100000.0 | nM | - |