Assay Detail
Binding
CHEMBL4374982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 mins by ethidium bromide staining based gel electrophoresis method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA topoisomerase 4 subunit A (CHEMBL4088) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.26 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583368 | — | — | 1 | 7.40 |
| CHEMBL4541988 | — | — | 1 | 7.30 |
| CHEMBL4530328 | — | — | 1 | 6.52 |
| CHEMBL4533152 | — | — | 1 | 6.52 |
| CHEMBL4536608 | — | — | 1 | 5.77 |
| CHEMBL4438807 | — | — | 1 | 5.77 |
| CHEMBL4476525 | — | — | 1 | 5.68 |
| CHEMBL4465361 | — | — | 1 | 5.52 |
| CHEMBL4467826 | — | — | 1 | 5.51 |
| CHEMBL4453061 | — | — | 1 | 5.40 |
| CHEMBL4554663 | — | — | 1 | 5.29 |
| CHEMBL4567626 | — | — | 1 | 5.26 |
| CHEMBL4570423 | — | — | 1 | 5.25 |
| CHEMBL4569403 | — | — | 1 | 5.17 |
| CHEMBL4537564 | — | — | 1 | 5.15 |
| CHEMBL4530941 | — | — | 1 | 5.12 |
| CHEMBL4538428 | — | — | 1 | 4.99 |
| CHEMBL4583024 | — | — | 1 | 4.95 |
| CHEMBL4549719 | — | — | 1 | 4.94 |
| CHEMBL4445613 | — | — | 1 | 4.93 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.89 |
| CHEMBL4575351 | — | — | 1 | 4.82 |
| CHEMBL4544202 | — | — | 1 | 4.40 |
| CHEMBL4548671 | — | — | 1 | 4.28 |
| CHEMBL4527338 | — | — | 1 | 4.28 |
| CHEMBL4451890 | — | — | 1 | 4.08 |
| CHEMBL4531900 | — | — | 1 | 4.05 |
| CHEMBL579300 | — | — | 1 | 4.00 |
| CHEMBL4515683 | — | — | 1 | - |
| CHEMBL4559061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583368 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4541988 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4533152 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4530328 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4536608 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4438807 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4476525 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4465361 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4467826 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4453061 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4554663 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4567626 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4570423 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4569403 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4537564 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4530941 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4538428 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4583024 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4549719 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4445613 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4575351 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4544202 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL4548671 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL4527338 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4451890 | — | IC50 | = | 83800.0 | nM | 4.08 |
| CHEMBL4531900 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL579300 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4557243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4544573 | — | IC50 | = | 489000.0 | nM | - |
| CHEMBL4574863 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4465692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4591085 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4538641 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4435611 | — | IC50 | = | 136900.0 | nM | - |
| CHEMBL4585210 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4453182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4441397 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4559061 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4515683 | — | IC50 | > | 100000.0 | nM | - |