Assay Detail
ADMET
CHEMBL4375009
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Cytotoxicity against human HepG2 cells after 48 hrs by Alamar blue staining-based fluorometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.46 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574863 | — | — | 1 | 4.60 |
| CHEMBL4583368 | — | — | 1 | 4.51 |
| CHEMBL4541988 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574863 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4583368 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4541988 | — | IC50 | = | 55000.0 | nM | 4.26 |