Assay Detail
Functional
CHEMBL4375036
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Cytotoxicity against human PBMC cells assessed as reduction in cell viability by CellTiter Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.57 |
| CHEMBL4580854 | — | — | 1 | 7.00 |
| CHEMBL4471761 | — | — | 1 | 5.24 |
| CHEMBL4437785 | — | — | 1 | 5.14 |
| CHEMBL4458214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4580854 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4471761 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4437785 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4458214 | — | IC50 | > | 10000.0 | nM | - |