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Assay Detail

CHEMBL4375134

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-infection by Nano-Glo luciferase assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type MT4
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2093867)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.
Liu Q, Cheng YY, Li W, Huang L, Asada Y, Hsieh MT, Morris-Natschke SL, Chen CH, Koike K, Lee KH.
J Med Chem (2019) 62 : 6958 -6971
PubMed 31343875 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 9.78 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4442196 1 10.05
CHEMBL3741746 1 9.89
CHEMBL4575056 1 9.85
CHEMBL4528495 1 9.82
CHEMBL4538431 1 9.77
CHEMBL4443190 1 9.74
CHEMBL4435580 1 9.66
CHEMBL4587471 1 9.44
CHEMBL4536366 1 -
CHEMBL4578026 1 -
CHEMBL4580556 1 -
CHEMBL4560772 1 -
CHEMBL4585270 1 -
CHEMBL4580586 1 -
CHEMBL4527508 1 -
CHEMBL4443186 1 -
CHEMBL4533733 1 -
CHEMBL4460926 1 -
CHEMBL4537465 1 -
CHEMBL4444766 1 -
CHEMBL4586553 1 -
CHEMBL4442856 1 -
CHEMBL4558004 1 -
CHEMBL4570883 1 -
CHEMBL4451784 1 -
CHEMBL4470135 1 -
CHEMBL4587134 1 -
CHEMBL4562111 1 -
CHEMBL4475196 1 -
CHEMBL4460901 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4442196 IC50 = 0.09 nM 10.05
CHEMBL3741746 IC50 = 0.13 nM 9.89
CHEMBL4575056 IC50 = 0.14 nM 9.85
CHEMBL4528495 IC50 = 0.15 nM 9.82
CHEMBL4538431 IC50 = 0.17 nM 9.77
CHEMBL4443190 IC50 = 0.18 nM 9.74
CHEMBL4435580 IC50 = 0.22 nM 9.66
CHEMBL4587471 IC50 = 0.36 nM 9.44
CHEMBL4536366 IC50 > 1.0 nM -
CHEMBL4578026 IC50 > 1.0 nM -
CHEMBL4580556 IC50 > 1.0 nM -
CHEMBL4560772 IC50 > 1.0 nM -
CHEMBL4585270 IC50 > 1.0 nM -
CHEMBL4580586 IC50 > 1.0 nM -
CHEMBL4527508 IC50 > 1.0 nM -
CHEMBL4443186 IC50 > 1.0 nM -
CHEMBL4533733 IC50 > 1.0 nM -
CHEMBL4460926 IC50 > 1.0 nM -
CHEMBL4537465 IC50 > 1.0 nM -
CHEMBL4444766 IC50 > 1.0 nM -
CHEMBL4586553 IC50 > 1.0 nM -
CHEMBL4442856 IC50 > 1.0 nM -
CHEMBL4558004 IC50 > 1.0 nM -
CHEMBL4570883 IC50 > 1.0 nM -
CHEMBL4451784 IC50 > 1.0 nM -
CHEMBL4470135 IC50 > 1.0 nM -
CHEMBL4587134 IC50 > 1.0 nM -
CHEMBL4562111 IC50 > 1.0 nM -
CHEMBL4475196 IC50 > 1.0 nM -
CHEMBL4460901 IC50 > 1.0 nM -