Assay Detail
Binding
CHEMBL4375135
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Agonist activity at Protein kinase C in human U1 cells infected with HIV-1 NL4-3 assessed as induction of HIV-1 p24 production after 72 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.40 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741746 | — | — | 1 | 9.72 |
| CHEMBL4587471 | — | — | 1 | 9.26 |
| CHEMBL4575056 | — | — | 1 | 9.22 |
| CHEMBL4444766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741746 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4587471 | — | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4575056 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4444766 | — | EC50 | > | 3.9 | nM | - |