Assay Detail

CHEMBL4376451

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Functional

Cytotoxicity against human PC3 cells assessed as reduction in cell growth

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

Open DB target context

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PC-3 (CHEMBL390) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

New thiazole-2(3H)-thiones containing 4-(3,4,5-trimethoxyphenyl) moiety as anticancer agents.

Ansari M, Shokrzadeh M, Karima S, Rajaei S, Fallah M, Ghassemi-Barghi N, Ghasemian M, Emami S.
Eur J Med Chem (2020) 185 : 111784 -111784
PubMed 31669850 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.96	8.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL106389	—	—	1	8.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL106389	—	IC50	=	1.1	nM	8.96