Assay Detail
Binding
CHEMBL4376478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.50 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.39 |
| CHEMBL4455690 | — | — | 1 | 6.34 |
| CHEMBL4474399 | — | — | 1 | 6.30 |
| CHEMBL4475205 | — | — | 1 | 6.10 |
| CHEMBL4560469 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 41.1 | nM | 7.39 |
| CHEMBL4455690 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4474399 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4475205 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4560469 | — | IC50 | = | 800.0 | nM | 6.10 |