Assay Detail
Binding
CHEMBL4377055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced membrane potential by FMP-2 dye based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 4 (CHEMBL1741219) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.18 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436705 | — | — | 1 | 5.39 |
| CHEMBL2396913 | — | — | 1 | 5.37 |
| CHEMBL4438838 | — | — | 1 | 5.28 |
| CHEMBL4440241 | — | — | 1 | 5.26 |
| CHEMBL1376358 | — | — | 1 | 4.99 |
| CHEMBL2396911 | — | — | 1 | 4.99 |
| CHEMBL2396912 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436705 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2396913 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4438838 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4440241 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1376358 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2396911 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2396912 | — | IC50 | = | 11000.0 | nM | 4.96 |