Assay Detail
Binding
CHEMBL4377058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPC3 expressed in HEK293 cells assessed as reduction in carbachol-induced membrane potential by FMP-2 dye based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 3 (CHEMBL2417348) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438838 | — | — | 1 | 4.71 |
| CHEMBL4436705 | — | — | 1 | 4.52 |
| CHEMBL1376358 | — | — | 1 | 4.31 |
| CHEMBL2396912 | — | — | 1 | - |
| CHEMBL4440241 | — | — | 1 | - |
| CHEMBL2396911 | — | — | 1 | - |
| CHEMBL2396913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438838 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4436705 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL1376358 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL2396912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4440241 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396913 | — | IC50 | > | 100000.0 | nM | - |