Assay Detail
Binding
CHEMBL4377068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at +100 mV by patch clamp assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 4 (CHEMBL4295971) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 10.52 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466522 | ZERENCOTREP | 2.0 | 1 | 10.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466522 | ZERENCOTREP | IC50 | = | 0.03 | nM | 10.52 |