Assay Detail
Binding
CHEMBL4377101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ORAI/STIM1 in thapsigargin treated rat RBL2H3 cells assessed as reduction in store-operated calcium entry after 5 mins by fura-2-AM dye based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.92 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101896 | — | — | 1 | 6.31 |
| CHEMBL4177187 | — | — | 1 | 6.27 |
| CHEMBL262766 | — | — | 1 | 6.23 |
| CHEMBL4460029 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101896 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4177187 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL262766 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4460029 | — | IC50 | = | 13080.0 | nM | 4.88 |