Assay Detail
Binding
CHEMBL4377133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formation of inosine using adenosine as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.61 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284483 | COFORMYCIN | 2.0 | 1 | 9.17 |
| CHEMBL1234234 | — | — | 1 | 8.57 |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284483 | COFORMYCIN | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL1234234 | — | Ki | = | 2.66 | nM | 8.57 |
| CHEMBL1580 | PENTOSTATIN | Ki | = | 8.2 | nM | 8.09 |