Assay Detail
Binding
CHEMBL4377150
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Inhibition of Plasmodium falciparum HGXPRT expressed in Escherichia coli BL21 (DE3) assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation using [5'-14C]IMP as substrate by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.43 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1233663 | — | — | 1 | 9.00 |
| CHEMBL1233603 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1233663 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1233603 | — | Ki | = | 14.0 | nM | 7.85 |