Assay Detail
Functional
CHEMBL4377153
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Antimalarial activity against synchronized Plasmodium falciparum K1 ring form infected in human erythrocytes assessed as reduction in parasite growth after 72 hrs by Hoechst 33258 staining based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.35 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286534 | — | — | 1 | 6.75 |
| CHEMBL261691 | — | — | 1 | 6.54 |
| CHEMBL261240 | — | — | 1 | 5.68 |
| CHEMBL1652265 | — | — | 1 | 5.22 |
| CHEMBL4458103 | — | — | 1 | 4.82 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 4.43 |
| CHEMBL4569377 | — | — | 1 | 4.00 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286534 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL261691 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL261240 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1652265 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4458103 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4569377 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL484 | ADEFOVIR | IC50 | > | 250000.0 | nM | - |