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Assay Detail

CHEMBL4377280

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxic activity in human A549 cells assessed as reduction in cell viability
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Triphenylphosphonium Analogues of Betulin and Betulinic Acid with Biological Activity: A Comprehensive Review.
Grymel M, Zawojak M, Adamek J.
J Nat Prod (2019) 82 : 1719 -1730
PubMed 31141361 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.30 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4464371 1 5.43
CHEMBL4514691 1 5.30
CHEMBL312687 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4464371 IC50 = 3700.0 nM 5.43
CHEMBL4514691 IC50 = 5000.0 nM 5.30
CHEMBL312687 IC50 = 6700.0 nM 5.17