Assay Detail
Binding
CHEMBL4377289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FL-H3K4me3 binding to recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by fluorescence polarization displacement assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.14 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109630 | — | — | 1 | 6.68 |
| CHEMBL4552020 | — | — | 1 | 6.61 |
| CHEMBL4588285 | — | — | 1 | 6.13 |
| CHEMBL1231795 | — | — | 1 | 5.13 |
| CHEMBL4450765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109630 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4552020 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4588285 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL1231795 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4450765 | — | IC50 | - | — | - |