Assay Detail
Binding
CHEMBL4377380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.48 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557190 | — | — | 1 | 8.40 |
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 8.30 |
| CHEMBL4469750 | — | — | 1 | 8.22 |
| CHEMBL4457060 | — | — | 1 | 8.15 |
| CHEMBL4571117 | — | — | 1 | 8.10 |
| CHEMBL4572855 | — | — | 1 | 8.10 |
| CHEMBL4566158 | — | — | 1 | 8.05 |
| CHEMBL4580625 | — | — | 1 | 7.92 |
| CHEMBL4559585 | — | — | 1 | 7.92 |
| CHEMBL4443834 | — | — | 1 | 7.92 |
| CHEMBL4476261 | — | — | 1 | 7.85 |
| CHEMBL4565054 | — | — | 1 | 7.82 |
| CHEMBL4543984 | — | — | 1 | 7.82 |
| CHEMBL4435079 | — | — | 1 | 7.80 |
| CHEMBL4474729 | — | — | 1 | 7.66 |
| CHEMBL4441840 | — | — | 1 | 7.55 |
| CHEMBL4537259 | — | — | 1 | 7.52 |
| CHEMBL4587924 | — | — | 1 | 7.47 |
| CHEMBL4468025 | — | — | 1 | 7.33 |
| CHEMBL4578980 | — | — | 1 | 7.29 |
| CHEMBL4582205 | — | — | 1 | 7.20 |
| CHEMBL4527672 | — | — | 1 | 7.19 |
| CHEMBL4572426 | — | — | 1 | 7.16 |
| CHEMBL4524832 | — | — | 1 | 7.11 |
| CHEMBL4577224 | — | — | 1 | 6.89 |
| CHEMBL4439617 | — | — | 1 | 6.66 |
| CHEMBL4534832 | — | — | 1 | 6.31 |
| CHEMBL4581296 | — | — | 1 | 6.03 |
| CHEMBL4543090 | — | — | 1 | 5.12 |
| CHEMBL4530035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557190 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4469750 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4457060 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4571117 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4572855 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4566158 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4580625 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4559585 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4443834 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4476261 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4565054 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4543984 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4435079 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4474729 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4441840 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4537259 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4587924 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4468025 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4578980 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4582205 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4527672 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4572426 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4524832 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4577224 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4439617 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4534832 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4581296 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4543090 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4530035 | — | IC50 | > | 10000.0 | nM | - |