Assay Detail
Binding
CHEMBL4377385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by in vitro patch clamp method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.80 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469750 | — | — | 1 | 5.17 |
| CHEMBL4559585 | — | — | 1 | 4.80 |
| CHEMBL4557190 | — | — | 1 | 4.42 |
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | - |
| CHEMBL4580625 | — | — | 1 | - |
| CHEMBL4476261 | — | — | 1 | - |
| CHEMBL4571117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469750 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4559585 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4557190 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | > | 80000.0 | nM | - |
| CHEMBL4580625 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4476261 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4571117 | — | IC50 | > | 80000.0 | nM | - |